Neuronal control of bodily function basic and clinical aspects vol 5 brain aging molecular biology the aging process and neurodegenerative disease. Molecular aging of the brain neuroplasticity and vulnerability to depression and other brain related disorders molecular aging of the brain overlaps with biological pathways implicated in multiple brain disorders porter nm chen kc et al calcium dysregulation in neuronal aging and alzheimers disease history and new directions . Fig 3 roles of gene responses in determining resistance and vulnerability to age related disease aging results in increased levels of oxidative stress metabolic disturbances. Huntingtons disease hd an autosomal dominant neurodegenerative disorder is characterized clinically by progressive cognitive impairment abnormalities of movement and neuropsychiatric symptoms onset usually occurs during the fourth or fifth decade of life and the disease symptoms and signs progress with aging with a mean survival of 15
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